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Furosemide Application

Chronic heart failure, pulmonary edema, hypertonic crisis, hydropic-ascitic syndrome with cirrhosis of the liver, kidney failure, nefrotichesky syndrome, expressed gipernatriemiya, hypercalcemia and gipermagniemiya.

Contraindications: Hypersensitivity (including to a sulfonamide), hepatic coma, severe violations of electrolyte balance, gipokaliemiya expressed the inadequacy of the functions of the liver and kidneys, oliguria for more than 24 h, anuria, gout, giperurikemiya, diabetes, or breach of tolerance to carbohydrates , decompensated mitral or aortic stenosis, increased pressure in the jugular vein over 10 mm Hg, hypertrophic cardiomyopathy with obstruction of left ventricular output tract, hypotension, myocardial infarction, systemic lupus erythematosus, pancreatitis, metabolic alkalosis.

Adverse effects: Hypertension, including postural, collapse, thromboembolism, throm (mostly elderly), gipokaliemiya, gipomagniemiya, hyponatremia, a breach of tolerance to glucose, giperurikemiya, gout, increased levels of cholesterol LPNP (at high doses), the violation KSCHS (gipohloremichesky alkalosis), giperkaltsiuriya, the violation of the functions of the liver , intrahepatic cholestasis, pancreatitis, diarrhea, constipation, nausea, vomiting, anorexia, loose inner ear, hearing loss, zatumanivanie vision, confusion, nervousness, headache, dizziness, paresthesia, weakness, muscle spasm, spasm of the bladder, chills, fever , thrombocytopenia, aplastic anemia, leukopenia, systemic vasculitis, interstitial nephritis, gematuriya, nekrotiziruyuschy angiitis, eksfoliativny dermatitis, erythema mnogoformnaya, impotence, photosensitization, hives, itchy skin.

Interaction: aminoglycosides, ethacrynic acid and cisplatin increased the ototoksichnost (especially when impaired renal function). Increases risk of kidney lesions on a background of amphotericin B. In the appointment of high doses of salicylates increases the risk of developing salitsilizma (competitive renal excretion), cardiac glycosides - gipokaliemii and related arrhythmias, corticosteroids - electrolyte imbalance. Decreases miorelaksiruyuschuyu activity tubokurarina, potentiator effect suktsinilholina. Decreases renal clearance (and increases the likelihood of intoxication) of lithium. Under the influence of furosemide increased the effect of inhibitors and antihypertensive APF funds, warfarin, diazoksida, teofillina declines - protivodiabeticheskih drugs, noradrenaline. Sukralfat and indometacin (due to inhibition of PG synthesis, disturbance in the plasma levels of renin and aldosterone excretion) reduce the effectiveness. Probenecid increases the concentration in serum (blocking excretion).

Overdosage: Symptoms: Hypertension, lowering OTSP, gipokaliemiya and gipohloremichesky alkaloz.Lechenie: the maintenance of vital functions.

Dosing and Administration: inside, in a daily dose of 20-60 mg, if necessary, may increase dose by 20-40 mg every 6-8 hours (high dose is divided into reception 2-3). V / m or / in - once, 20-40 mg (if needed - increasing doses of 20 mg every 2 h). Jet in / to make the introduction slowly, within 1-2 minutes. In high doses (80-240 mg or more) into the / in drops, at a rate no higher than 4 mg / min. The maximum daily dose - 600 mg.

Precautions: If there is ascites without peripheral edema recommended doses for further diuresis in the volume of no more than 700-900 ml / day to avoid the development of oliguria, azotemii and violations of electrolyte metabolism. To exclude the phenomenon of "rebound" in the treatment of hypertension appoint at least 2 times a day. It should be borne in mind that a long reception can lead to weakness, fatigue, lowering blood pressure and cardiac output, and excessive diuresis with myocardial infarction with stagnant phenomena in the small circle of blood circulation may contribute to the development kardiogennogo shock. There is a need for a temporary lifting of (several days) before the appointment of inhibitors of APF. During the first months of treatment is recommended to control blood pressure, levels of electrolytes (especially potassium), CO2, creatinine, urea nitrogen, uric acid, periodic determination of activity of liver enzymes, the level of calcium and magnesium content of glucose in the blood and in urine (diabetes). When you save oliguria within 24 h of furosemide should be abolished. It should not be used during the drivers of vehicles and people, a profession which is related to increased concentration.

Cautions: For breeding to be used isotonic solution of sodium chloride or glucose with a pH lower than 5.5.

Trading names of preparations with the active ingredient furosemide * (Furosemide *)

Laziks (Lasix) furosemide-N.S. (Furosemide-NS) furosemide injection 1% (Solutio Furosemidi pro injectionibus 1%), furosemide (Furosemide) furosemide-ratiofarm (Furosemid-ratiopharm) furosemide tablet 0,04 g (Tabulettae Furosemidi 0,04 g) Nikomed furosemide (Furosemide Nycomed ) furosemide-Ros (Furosemid-Ros) Tablets 40 mg furosemide (Furosemide tablets 40 mg) furosemide-Darnitsa (Furosemid-Darnitsa) furosemide-Teva (Furosemide-Teva) furosemide-Milve (Furosemide-Milve) furosemide-Fereyn (Furosemide-Ferein )

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Furosemide (Furosemidum)

Furosemide (Furosemidum). 4-Chloro-M-(2-furilmetil)-5-sulfamoilantranilovaya acid. Synonyms: Laziks, Furantril, Afsamid, Arasemide, Diusemide, Diuzol, Dryptal, Edefrusex, Errolon, Franyl, Frugex, Frusemide, Frusolon, Furanthril, Furantral, Furfan, Furomex, Furosan, Furosemide, Fusid, Katlex, Kinex, Lasilix, Lasix, Nicorol, Profemin, Protargen, Rasisemid, Renex, Salix, Seguril, Trofurit, Uritol, Urosemid and other white crystalline powder. Insoluble in water. By its chemical structure (presence of chlorine atom and sulfanamidnoy groups with phenyl nucleus) has similarities with dihlotiazidom and close to the compounds. Is a strong diuretic furosemide (salureticheskim) tool. Effective oral and parenteral application. Diuretic effect associated with inhibition reabsorbtsii N and Cl ions, and this inhibition is observed not only in proximal but also in the distal tortuosity canals, and in the ascending loop Genle department. Reabsorbtsiya potassium as oppressed, but to a much lesser extent. Notable oppression is carbonic anhydrase. The product is equally effective in the context of acidosis and alkalosis. Diuretic effect is most pronounced during the first 2 days of taking the medication, but does not disappear even with long-term treatment. The drug acts quickly. After intravenous diuretic effect begins within a few minutes after taking the inside - in the first hour. Duration of action after a single intravenous 1.5 - 3 h after ingestion - 4 h or more. The rapid effect of intravenous furosemide allows use in urgent cases (pulmonary edema, brain, etc.). Furosemide is used as diuretics in the stagnant phenomena in the small and large circle of blood circulation caused by heart failure, liver cirrhosis with portal hypertension with the phenomena, chronic and acute renal failure, pulmonary edema and brain poisoning barbiturates, eclampsia. In contrast to thiazides, furosemide does not lower glomerular filtration, and its use in connection with that in chronic renal failure (if there is testimony to the use of diuretics). In several cases, furosemide has a diuretic effect in the lack of effectiveness of other drugs. Effectiveness of furosemide in the treatment of patients with circulatory insufficiency due not only to the diuretic effect, but also expanding to the direct effect on peripheral vessels. The first (early) phase, growing in the first 30 min after injection of the drug depends on its effect on peripheral vessels, and the second (late) phase, growing in 1 - 2 h after injection, associated with diuretic effects. Furosemide has also antihypertensive effect. The drug is effective in various forms of hypertension, including severe forms, in which other saluretiki ineffective. Mechanism of antihypertensive action is mainly the same as in the application tiazidnyh diuretics. Applied also to furosemide kupirovaniya heavy hypertonic crisis. For long-term therapy of patients with hypertension is recommended dihlotiazid (in connection with its less dramatic and more long-term effect). Furosemide may be used in combination with other antihypertensives drugs. Appoints furosemide inside to eat, intravenously and intramuscularly, selecting doses depending on the severity of the disease and the observed effect. Usually taken by 0.04 g (40 mg = 1 tablet) 1 times a day (morning), with little effect of the dose increased to 0,08 - 0,12 g (up to 0.16 g) per day (in 2 - 3 Admission to the interval 6 h). After reduction of edema given in lower doses with an interval 1 - 2 days. In hypertension, appoint furosemide on 20 - 40 mg (1 / 2 - 1 tablet) 1 times a day. In the accompanying heart failure daily dose can be increased to 80 mg. When you receive along with hypotensive drugs appoint furosemide usually 1 / 2 tablets (20 mg) 1 - 2 times a day. If you can not use of the drug inside (with loss of consciousness, a state of absorption from the intestines) and with the need for a rapid effect of furosemide injected intramuscularly or intravenously. Injected into a vein slowly jet. Doses in the parenteral use of 20 - 60 mg 1 - 2 times a day. After the necessary transition effects to receive the drug inside. In the application of furosemide may be nausea, diarrhea, skin hyperemia, pruritus, hypotension, reversible deterioration of hearing, interstitial nephritis. Due to enhanced diuresis may be dizziness, depression, muscle weakness, thirst. Can develop gipokaliemiya, giperurikemiya, urikozuriya, hyperglycemia. If you have adverse reactions the dose should be reduced or cancel the product. It is inappropriate to combine with Cephalosporins furosemide, gentamicin and other drugs that provide nefrotoksicheskoe operation. Treatment should be conducted against the background of a diet rich in potassium. Side effects: the first half of pregnancy, gipokaliemiya, hepatic coma, terminal stage renal failure, mechanical occlusion of the urinary tract. Method of production: tablets of 0.04 g per pack of 50 pieces, 1% solution in ampoules of 2 ml (0.02 g) per pack of 5 ampoules. Storage: List B.
> swap

Furosemide following survey

Do not freeze the medication.

Do not store medicine in the bathroom. Do not expose him exposed to high temperatures, moisture or direct sunlight.

CAPTOPRIL, tsefaleksin, activated charcoal, hlorpropamid, cholestyramine, tsisplatil, digoxin, lithium salts, propranol, teofillin cause "clinically vysokoznachitelnye" or "clinically significant" interaction when used together with this drug. Some other drugs, particularly those relating to the same groups as listed below are described in the interaction with the drug can cause serious side effects. With an increasing number of new drugs approved for sale, and increases the risk of adverse interactions with the joint application, which is often identified with the old drugs. Be vigilant. Be sure to tell your doctor about all medicines you take, and pay special attention to the doctor if you are taking any medications that interact with the drug before.

Immediately call a doctor if you experience: dry mouth, severe thirst, violations of the heart rate, sudden shifts of mood, cramps or pain in muscles, severe stomach pain accompanied by nausea or vomiting, unusual tiredness or weakness, weak pulse, ksantopsiya (yellow pall before my eyes), cough or hoarseness, fever or chills, joint pains, lower back or sides, painful or difficult urination, small red dots on the skin, the noise in the ears or hearing loss, skin rashes or hives, unusual bleeding or bruising, yellow eyes or skin.

Call a doctor if you constantly, for a sufficiently long period of time, you are observed: dizziness, weakness, diarrhea, loss of appetite, discomfort in the stomach, headache, confusion of view, the "veil before the eyes, premature semyaizverzhenie or Erectile Dysfunction.

Ask your physician if any of the following survey, you should periodically take place during the reception of this drug: blood pressure measurement, clinical analysis of blood tests to determine the level of sodium, potassium, chloride ion, calcium, sugar and uric acid, the functional Samples of liver, kidney function tests, hearing checks, weight.

During pregnancy the drug should be used only if absolutely necessary. Before taking this drug should be informed of his attending physician, if you are pregnant or have any suspicion that you are pregnant.