Furosemide (Furosemidum)

Furosemide (Furosemidum). 4-Chloro-M-(2-furilmetil)-5-sulfamoilantranilovaya acid. Synonyms: Laziks, Furantril, Afsamid, Arasemide, Diusemide, Diuzol, Dryptal, Edefrusex, Errolon, Franyl, Frugex, Frusemide, Frusolon, Furanthril, Furantral, Furfan, Furomex, Furosan, Furosemide, Fusid, Katlex, Kinex, Lasilix, Lasix, Nicorol, Profemin, Protargen, Rasisemid, Renex, Salix, Seguril, Trofurit, Uritol, Urosemid and other white crystalline powder. Insoluble in water. By its chemical structure (presence of chlorine atom and sulfanamidnoy groups with phenyl nucleus) has similarities with dihlotiazidom and close to the compounds. Is a strong diuretic furosemide (salureticheskim) tool. Effective oral and parenteral application. Diuretic effect associated with inhibition reabsorbtsii N and Cl ions, and this inhibition is observed not only in proximal but also in the distal tortuosity canals, and in the ascending loop Genle department. Reabsorbtsiya potassium as oppressed, but to a much lesser extent. Notable oppression is carbonic anhydrase. The product is equally effective in the context of acidosis and alkalosis. Diuretic effect is most pronounced during the first 2 days of taking the medication, but does not disappear even with long-term treatment. The drug acts quickly. After intravenous diuretic effect begins within a few minutes after taking the inside - in the first hour. Duration of action after a single intravenous 1.5 - 3 h after ingestion - 4 h or more. The rapid effect of intravenous furosemide allows use in urgent cases (pulmonary edema, brain, etc.). Furosemide is used as diuretics in the stagnant phenomena in the small and large circle of blood circulation caused by heart failure, liver cirrhosis with portal hypertension with the phenomena, chronic and acute renal failure, pulmonary edema and brain poisoning barbiturates, eclampsia. In contrast to thiazides, furosemide does not lower glomerular filtration, and its use in connection with that in chronic renal failure (if there is testimony to the use of diuretics). In several cases, furosemide has a diuretic effect in the lack of effectiveness of other drugs. Effectiveness of furosemide in the treatment of patients with circulatory insufficiency due not only to the diuretic effect, but also expanding to the direct effect on peripheral vessels. The first (early) phase, growing in the first 30 min after injection of the drug depends on its effect on peripheral vessels, and the second (late) phase, growing in 1 - 2 h after injection, associated with diuretic effects. Furosemide has also antihypertensive effect. The drug is effective in various forms of hypertension, including severe forms, in which other saluretiki ineffective. Mechanism of antihypertensive action is mainly the same as in the application tiazidnyh diuretics. Applied also to furosemide kupirovaniya heavy hypertonic crisis. For long-term therapy of patients with hypertension is recommended dihlotiazid (in connection with its less dramatic and more long-term effect). Furosemide may be used in combination with other antihypertensives drugs. Appoints furosemide inside to eat, intravenously and intramuscularly, selecting doses depending on the severity of the disease and the observed effect. Usually taken by 0.04 g (40 mg = 1 tablet) 1 times a day (morning), with little effect of the dose increased to 0,08 - 0,12 g (up to 0.16 g) per day (in 2 - 3 Admission to the interval 6 h). After reduction of edema given in lower doses with an interval 1 - 2 days. In hypertension, appoint furosemide on 20 - 40 mg (1 / 2 - 1 tablet) 1 times a day. In the accompanying heart failure daily dose can be increased to 80 mg. When you receive along with hypotensive drugs appoint furosemide usually 1 / 2 tablets (20 mg) 1 - 2 times a day. If you can not use of the drug inside (with loss of consciousness, a state of absorption from the intestines) and with the need for a rapid effect of furosemide injected intramuscularly or intravenously. Injected into a vein slowly jet. Doses in the parenteral use of 20 - 60 mg 1 - 2 times a day. After the necessary transition effects to receive the drug inside. In the application of furosemide may be nausea, diarrhea, skin hyperemia, pruritus, hypotension, reversible deterioration of hearing, interstitial nephritis. Due to enhanced diuresis may be dizziness, depression, muscle weakness, thirst. Can develop gipokaliemiya, giperurikemiya, urikozuriya, hyperglycemia. If you have adverse reactions the dose should be reduced or cancel the product. It is inappropriate to combine with Cephalosporins furosemide, gentamicin and other drugs that provide nefrotoksicheskoe operation. Treatment should be conducted against the background of a diet rich in potassium. Side effects: the first half of pregnancy, gipokaliemiya, hepatic coma, terminal stage renal failure, mechanical occlusion of the urinary tract. Method of production: tablets of 0.04 g per pack of 50 pieces, 1% solution in ampoules of 2 ml (0.02 g) per pack of 5 ampoules. Storage: List B.
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