Furosemide Application

Chronic heart failure, pulmonary edema, hypertonic crisis, hydropic-ascitic syndrome with cirrhosis of the liver, kidney failure, nefrotichesky syndrome, expressed gipernatriemiya, hypercalcemia and gipermagniemiya.

Contraindications: Hypersensitivity (including to a sulfonamide), hepatic coma, severe violations of electrolyte balance, gipokaliemiya expressed the inadequacy of the functions of the liver and kidneys, oliguria for more than 24 h, anuria, gout, giperurikemiya, diabetes, or breach of tolerance to carbohydrates , decompensated mitral or aortic stenosis, increased pressure in the jugular vein over 10 mm Hg, hypertrophic cardiomyopathy with obstruction of left ventricular output tract, hypotension, myocardial infarction, systemic lupus erythematosus, pancreatitis, metabolic alkalosis.

Adverse effects: Hypertension, including postural, collapse, thromboembolism, throm (mostly elderly), gipokaliemiya, gipomagniemiya, hyponatremia, a breach of tolerance to glucose, giperurikemiya, gout, increased levels of cholesterol LPNP (at high doses), the violation KSCHS (gipohloremichesky alkalosis), giperkaltsiuriya, the violation of the functions of the liver , intrahepatic cholestasis, pancreatitis, diarrhea, constipation, nausea, vomiting, anorexia, loose inner ear, hearing loss, zatumanivanie vision, confusion, nervousness, headache, dizziness, paresthesia, weakness, muscle spasm, spasm of the bladder, chills, fever , thrombocytopenia, aplastic anemia, leukopenia, systemic vasculitis, interstitial nephritis, gematuriya, nekrotiziruyuschy angiitis, eksfoliativny dermatitis, erythema mnogoformnaya, impotence, photosensitization, hives, itchy skin.

Interaction: aminoglycosides, ethacrynic acid and cisplatin increased the ototoksichnost (especially when impaired renal function). Increases risk of kidney lesions on a background of amphotericin B. In the appointment of high doses of salicylates increases the risk of developing salitsilizma (competitive renal excretion), cardiac glycosides - gipokaliemii and related arrhythmias, corticosteroids - electrolyte imbalance. Decreases miorelaksiruyuschuyu activity tubokurarina, potentiator effect suktsinilholina. Decreases renal clearance (and increases the likelihood of intoxication) of lithium. Under the influence of furosemide increased the effect of inhibitors and antihypertensive APF funds, warfarin, diazoksida, teofillina declines - protivodiabeticheskih drugs, noradrenaline. Sukralfat and indometacin (due to inhibition of PG synthesis, disturbance in the plasma levels of renin and aldosterone excretion) reduce the effectiveness. Probenecid increases the concentration in serum (blocking excretion).

Overdosage: Symptoms: Hypertension, lowering OTSP, gipokaliemiya and gipohloremichesky alkaloz.Lechenie: the maintenance of vital functions.

Dosing and Administration: inside, in a daily dose of 20-60 mg, if necessary, may increase dose by 20-40 mg every 6-8 hours (high dose is divided into reception 2-3). V / m or / in - once, 20-40 mg (if needed - increasing doses of 20 mg every 2 h). Jet in / to make the introduction slowly, within 1-2 minutes. In high doses (80-240 mg or more) into the / in drops, at a rate no higher than 4 mg / min. The maximum daily dose - 600 mg.

Precautions: If there is ascites without peripheral edema recommended doses for further diuresis in the volume of no more than 700-900 ml / day to avoid the development of oliguria, azotemii and violations of electrolyte metabolism. To exclude the phenomenon of "rebound" in the treatment of hypertension appoint at least 2 times a day. It should be borne in mind that a long reception can lead to weakness, fatigue, lowering blood pressure and cardiac output, and excessive diuresis with myocardial infarction with stagnant phenomena in the small circle of blood circulation may contribute to the development kardiogennogo shock. There is a need for a temporary lifting of (several days) before the appointment of inhibitors of APF. During the first months of treatment is recommended to control blood pressure, levels of electrolytes (especially potassium), CO2, creatinine, urea nitrogen, uric acid, periodic determination of activity of liver enzymes, the level of calcium and magnesium content of glucose in the blood and in urine (diabetes). When you save oliguria within 24 h of furosemide should be abolished. It should not be used during the drivers of vehicles and people, a profession which is related to increased concentration.

Cautions: For breeding to be used isotonic solution of sodium chloride or glucose with a pH lower than 5.5.

Trading names of preparations with the active ingredient furosemide * (Furosemide *)

Laziks (Lasix) furosemide-N.S. (Furosemide-NS) furosemide injection 1% (Solutio Furosemidi pro injectionibus 1%), furosemide (Furosemide) furosemide-ratiofarm (Furosemid-ratiopharm) furosemide tablet 0,04 g (Tabulettae Furosemidi 0,04 g) Nikomed furosemide (Furosemide Nycomed ) furosemide-Ros (Furosemid-Ros) Tablets 40 mg furosemide (Furosemide tablets 40 mg) furosemide-Darnitsa (Furosemid-Darnitsa) furosemide-Teva (Furosemide-Teva) furosemide-Milve (Furosemide-Milve) furosemide-Fereyn (Furosemide-Ferein )